I have had an Anole lizard for about 3 years now and he does this a lot.He willfall asleep in my hand or wherever i put him.Sometimes he'll close one eye and keep the other open..My suggestions
watch it-if it seems to be weak best bet would be bring it to the vets office
Is he/she eating- i had to force feed me anole for a week because he couldn't eat on his own
Check for dehydration- when a lizard is dehydrated they arent active,their eyes are sunken in and they don't eat a lot.
Is it alone?- if it has a cage buddy separate them for a night or too so that they don't wake each other up (mine do that sometimes)
My Anole is partially paralysed from the waste down (he can move his legs and tail but cant walk,he has to pull himself a round)because a bird broke his back when he was wild..
If your anole gets really bad take it to the vet,it may either be sick or just tired
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