Generally no.
But if that mac address is currently contacting you, you can usually do a NETSTAT-A and see the mac address translation for each ip address. Then you'll know which IP address to ping.
If you have access to the router (Cisco) that routes for the computer's local
network, then look in the arp table to find the MAC address:
Command > sh arp | inc mac address [0000.0000.0000]
Return will be > : internet 198.25.15.2 5 0000.0000.0000 ARPA FastEthernet0/0 or
whatever the ip address is and the mac address.
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