What harm can cause endotoxin in the body?

Endotoxins, which are components of the outer membrane of Gram-negative bacteria, can trigger severe inflammatory responses in the body. When released into the bloodstream, they can lead to sepsis, characterized by widespread inflammation, organ dysfunction, and potentially death. High levels of endotoxins can also cause fever, shock, and damage to blood vessels, resulting in increased permeability and fluid loss. This cascade of effects underscores the importance of managing infections caused by Gram-negative bacteria to prevent endotoxin-related complications.