The key differences between the Nikon D810 and D3300 cameras are in their sensor size, resolution, autofocus system, and overall features. The D810 has a full-frame sensor, higher resolution (36.3 megapixels), more advanced autofocus system, and additional features like a larger ISO range and better build quality compared to the D3300, which has a smaller APS-C sensor, lower resolution (24.2 megapixels), basic autofocus system, and fewer advanced features.
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