What is a FISH test with leukemia?

A FISH (Fluorescence In Situ Hybridization) test is a genetic analysis used to detect specific chromosomal abnormalities associated with leukemia. It involves using fluorescent probes that bind to particular DNA sequences, allowing visualization of chromosomal changes such as translocations, deletions, or amplifications in leukemia cells. This test helps in diagnosing the type of leukemia, assessing prognosis, and guiding treatment decisions. FISH is particularly useful for identifying genetic markers like the Philadelphia chromosome in chronic myeloid leukemia (CML).