How long to keep your female who is in heat away from males?

It's recommended to keep a female dog in heat away from male dogs for at least three weeks, which is typically the duration of her heat cycle. During this time, she can attract males and may become pregnant if mating occurs. To prevent unwanted breeding, secure her in a controlled environment and supervise her interactions with other dogs. If you're not planning to breed her, consider spaying her after her heat cycle.