Doxycycline should be taken as prescribed by a healthcare provider, usually either once or twice daily. It's best to take it with a full glass of water to help prevent irritation of the esophagus and to ensure proper absorption. Avoid taking it right before bedtime or lying down for at least 30 minutes after ingestion to minimize the risk of esophageal irritation. Additionally, it should be taken with food if stomach upset occurs.
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