Can Prednisone cause water retention

Yes, prednisone can cause water retention as a side effect. This occurs because the medication can influence the balance of electrolytes and fluid in the body, leading to increased sodium retention and fluid buildup. As a corticosteroid, prednisone can also affect hormone levels that regulate fluid balance. If you experience significant swelling or weight gain while on prednisone, it's important to consult your healthcare provider.