Which mutations are the most dangerous?

The most dangerous mutations are often those that significantly alter the function of critical genes, such as oncogenes and tumor suppressor genes, leading to cancer. Additionally, mutations that confer antibiotic resistance in bacteria or antiviral resistance in viruses can pose serious public health threats. Other harmful mutations may affect essential proteins involved in fundamental biological processes, potentially leading to severe genetic disorders. Overall, the impact of a mutation depends on its context, including the specific gene affected and the environment in which it occurs.