The Louisiana Purchase in 1803 doubled the size of the United States, raising significant questions about the expansion of slavery into new territories. As settlers moved westward, the debate intensified over whether these new lands would be free or slave-holding, leading to increased sectional tensions. This conflict was exemplified by events such as the Missouri Compromise of 1820, which attempted to balance the admission of slave and free states, further entrenching slavery as a central issue in American politics. Ultimately, the expansion of U.S. territory through the Louisiana Purchase catalyzed a national debate over slavery that would culminate in the Civil War.
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