Chronic Obstructive Pulmonary Disease (COPD) is primarily caused by smoking, with cigarettes accounting for approximately 80-90% of COPD-related cases. While exact global death tolls can vary, the World Health Organization estimates that COPD contributes to over 3 million deaths annually, with a significant proportion of these deaths linked directly to smoking. Therefore, smoking is a leading risk factor for COPD mortality worldwide.
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