Yes, Rh factor negative blood can skip a generation due to the inheritance pattern of the Rh factor gene. The Rh factor is determined by a dominant (Rh+) and recessive (Rh-) allele, meaning that two Rh- parents will always produce Rh- offspring, but an Rh+ parent can carry either one Rh+ or one Rh- allele, potentially passing on the negative trait. This genetic variability can lead to Rh- individuals appearing in subsequent generations even if they were not present in the immediate previous one. Documented evidence includes genetic studies that illustrate how recessive traits can be inherited across generations.
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