Jesus referred to the "generation of vipers" primarily in the context of criticizing the religious leaders of his time, particularly the Pharisees and Sadducees. He used this phrase to highlight their hypocrisy, moral corruption, and failure to recognize the truth of his message. This condemnation is found in passages such as Matthew 12:34 and Matthew 23:33, where he rebukes them for their deceitful nature and their role in leading others astray.
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