A:
In the three synoptic gospels, Jesus prayed in the Garden of Gethsemane. He suffered alone and in agony, asking God that, if possible, he take this cup (his destiny to be crucified) away. In the Gospels of Matthew and Mark, his last Words on the cross, when he finally realised that God had not heard his prayers in the garden, were, "My God. My God. Why hast thou forsaken me?" Luke's Gospel has the prayer in the Garden, but not Jesus' later realisation that God had forsaken him.
For theological reasons, John's Gospel does not have the unanswered prayer in the Garden, rather a triumphant prayer before reaching the Garden.
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