Is it safe to take cyclobenzaprine hydrocodone and zyprexa?

There could be complications from adding the cyclobenzaprine to the mixture. Promethazine is sometimes mixed with opiates similar to hydrocodone in pharmaceutical preparations. The combination of promethazine and hydrocodone taken orally should be safer than the combination of all three, be aware that potentially dangerous interactions could still occur. Cyclobenzaprine should not be taken simultaneously with other CNS depressants (such as promethazine and hydrocodone). Also, the combination of just promethazine and hydrocodone will still cause powerful sedation with lack of coordination and possible dizziness. Do not drive under the influence of these drugs.