What do sickle shaped red blood cells do in capillaries and vesseles?

Sickle-shaped red blood cells can obstruct blood flow in capillaries and vessels due to their abnormal shape, which makes them rigid and less flexible. This blockage can lead to reduced oxygen delivery to tissues and organs, causing pain and potential complications such as organ damage. Additionally, the sickle cells can break down more quickly than normal red blood cells, leading to anemia. Overall, their presence in the circulatory system disrupts normal blood flow and oxygen transport.