What is the animal model for osteoarthritis?

The most commonly used animal models for osteoarthritis (OA) include the surgically induced models, such as the anterior cruciate ligament transection (ACLT) and the medial meniscus resection (MMT) in rodents. These models simulate the mechanical and biological changes seen in human OA, allowing researchers to study disease progression and test therapeutic interventions. Additionally, spontaneous OA models, like aged mice or dogs, are also utilized to mimic the natural development of the disease. These models provide valuable insights into the pathophysiology of OA and aid in the evaluation of potential treatments.