Can fatigue cause death

Fatigue by itself is a sign, a symptom. In and of itself, ordinary fatigue would not be seen as a life threatening condition. However the cause of the fatigue is another matter. There could be an underlying condition in some cases that is life threatening and this could only be clarified by physicians. Also, ordinary fatigue can be and is routinely implicated in accidental deaths during the operation of machinery or automobiles, or while engaging in otherwise dangerous or very exacting activities like skiing, diving, climbing.