How many people contract Reye's syndrome per year?

Reye's syndrome is a rare but serious condition that primarily affects children and teenagers recovering from viral infections, particularly influenza and chickenpox. The incidence of Reye's syndrome has significantly decreased since the 1980s, largely due to public health campaigns warning against the use of aspirin in young patients. Currently, it is estimated that there are about 1 to 3 cases per million children per year in the United States. Due to its rarity, overall annual cases are low, often reported as fewer than 100 cases in the country.