Can benedryl make you high

Yes.

And taking high dosages causes seizures, brain damage, and death.
Short answer; Yes. Benedryl or namely Diphenhydramine(the chemical name) can give you a feeling of euphoria. It is not safe to take in large amounts and should not be used in this manner. but if you are going to BE VERY CAREFUL! 25-50 mgs is the normal dose. if you take more than that you could go into respiratory or cardiac arrest. (your heart stops beating, or you stop breathing). Diphenhydramine is commonly used as a sleep aid and it will make you VERY drowsy. so even if you do feel a little 'high' you will likely fall asleep and not even remember it. DO NOT EVER, EVER EXCEED 100 MG'S!!! you could die.