It depends on the delivery method.years ago you could literaly walk in a [pharmacy and obtain a product called paragoric for babies that was teething.The parents would take a bit on their finger and rub on a babies gums to ease pain from teething.It was taken of the market a an over the counter medication years ago for the junkies were separating the morphine out of it and injecting it. So your answer would be, as young as a baby that is starting to tooth out..but in small doses
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