Cephalosporins are not the first-line treatment for syphilis; penicillin, particularly benzathine penicillin G, is the standard and most effective treatment. While cephalosporins may have some activity against Treponema pallidum, the bacterium causing syphilis, they are not recommended or proven to cure the infection. Therefore, it's important to follow established treatment guidelines and use penicillin for syphilis management.
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