What is the highest denomination of US currency ever printed?

The largest denomination of currency ever printed by the Bureau of Engraving and Printing (BEP) was the $100,000 Series 1934 Gold Certificate featuring the portrait of President Wilson. Only 42,000 were printed and they were only used for transferring large amounts of money between government departments.

The highest denomination ever printed for use in circulation was $10,000. Other high-denomination notes were $5000, $1000, and $500.

The present denominations of US currency in production are $1, $2, $5, $10, $20, $50 and $100.

Printing of high-value notes was suspended in 1945, although the last ones were all part of the 1934 series and carry that date regardless of what year they were actually issued. Banks were allowed to distribute large bills up till 1969. President Nixon issued an order that year halting the practice because large bills were being heavily used by organized criminals to hide illegal transactions.

High-denomination bills were never withdrawn so technically they're still legal tender, but it would be foolish to spend one because they're worth much more to collectors.