Why doesn't my ePSXe run Isos files of the games?

There could be several reasons why ePSXe isn't running ISO files. First, ensure that the ISO files are properly created and not corrupted; you can verify this by trying to run them on a different emulator or checking their integrity. Additionally, make sure you have the correct BiOS file configured, as ePSXe requires it to function correctly. Lastly, check your settings in ePSXe to ensure that the proper plugin is selected for reading CD images.