DNA in prokaryotes is typically circular and exists as a single chromosome, while eukaryotic DNA is linear and organized into multiple chromosomes. Prokaryotic DNA is not associated with histones and is found in the cytoplasm, whereas eukaryotic DNA is wrapped around histones and located within a membrane-bound nucleus. Additionally, eukaryotic cells have more complex DNA structures, including introns and regulatory sequences, which are less common in prokaryotes.
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