What pharmacologic activity do amphetamine phenylephrine and methedrine have in common?

Amphetamine, phenylephrine, and methamphetamine (often referred to as methedrine) all exhibit stimulant properties that primarily affect the central nervous system. They increase the release of neurotransmitters such as norepinephrine and dopamine, leading to heightened alertness, increased energy, and elevated mood. Additionally, phenylephrine acts as a selective alpha-1 adrenergic agonist, primarily causing vasoconstriction, while amphetamines have broader effects on neurotransmitter release. However, the commonality lies in their stimulatory effects and enhancement of sympathetic nervous system activity.