Mechanism of Action: Like the tricyclics, venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), exert their antidepressant effects by inhibiting the reuptake of both serotonin and norepinephrine. Both parent and metabolite also have weak inhibitory effects on the reuptake of dopamine but, unlike the tricyclics, exert no in vitro activity at histaminergic, muscarinic, or ›A-adrenergic receptors, which accounts for its lack of anticholinergic, sedative, and cardiovascular side effects frequently observed with the tricyclic antidepressants. However, despite the claims of minimal muscarinic receptor activity, anticholinergic side effects may still occur with venlafaxine.
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