What are two factors that contribute to a detrimental well-being?

Two factors that contribute to detrimental well-being are chronic stress and lack of social support. Chronic stress can lead to physical and mental health issues, including anxiety and depression, while a lack of social support can exacerbate feelings of isolation and helplessness. Together, these factors can create a negative feedback loop that further impacts overall well-being. Addressing both can significantly improve an individual's quality of life.