Will you fail a drug test if you take Vyvanse?

Yes, taking Vyvanse (lisdexamfetamine) can result in a positive drug test, as it is an amphetamine. Standard drug tests often screen for amphetamines, and Vyvanse can be detected in urine for several days after use. If you are prescribed Vyvanse, it's advisable to inform the testing administrator beforehand to avoid any misunderstandings.