However much your doctor prescribes, or pharmacist recommends. Hydrocodone in a overdoses can cause respiratory depression or arrest and lead to brain damage or death if not treated. Any sedative, muscle relaxant, or anti-convulsive can cause major drug interactions with hydrocodone. In higher recreational doses, the homatropine (a compound related to the deliriant atropine) becomes significant as well, and can produce additional negative side effects. In fact, the homatropine is added to deter abuse. Therefore, the prescribed dose, usually starting around a volume corresponding to 5mg hydrocodone, it recommended.
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