A Prayer for Owen Meany title significance?

Owen kills Tabby when he hits a foul ball that then hits her in the head.

John's quest to figure out his dad's identity is put on hold when Owen accidentally kills Tabby. Not only does John lose his mother, whom he loves dearly, but now his father's identity is even more of a mystery. Tabby's death also has major implications for Owen: he becomes convinced that it's a sign from God that he is God's Instrument. The event of Tabby's death also presents John and Owen with a difficult challenge - how can a friendship go back to normal when you've killed your best friend's mom