The closest Galaxy to us (apart form the Milkyway in which we sit), is the The Canis Major Dwarf Galaxy (an irregular galaxy) located about 25,000 light-years away from our Solar System. Then there are the two satellite galaxies to ours, the large and small Magellanic Clouds. The LMC lies about 160,000 light years away and while the SMC is around 200,000 light years away.
After these comes the Andromeda Galaxy, which is a separate spiral galaxy approximately 2.5 million light-years from Earth.
Note, there may be some closer remnants of galaxies that the Milky Way has consumed that could be argued to be closer.
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