GDDR5 and DDR3 are different types of memory used for different purposes; GDDR5 is typically used in graphics cards, while DDR3 is used in system RAM. A graphics card with GDDR5 memory can be installed in a system that uses DDR3 RAM, as they operate independently. However, the overall performance will depend on the compatibility of the graphics card with the motherboard and the CPU, not the type of system RAM.
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