How do you get shoe polish off your hands?

Shoe polish is a complex mixture with organic hydrophobic molecules. The stain will probably not come out of your hands, but you can get the residue off by washing your hands multiple times with large amounts of soap. You can also try mechanic's soap (I like the brand Fast Orange, but there are many out there) - this stuff will cut engine grease, so it'll also cut through shoe polish. If you don't have this, you can try rubbing alcohol or hair shampoo, both of which should be able to dissolve the grease components.