What are examples of harmful mutations in human?

Mad Max, the first movie of the Mad Max franchise, is a 1979 Australian dystopian action film directed by George Miller and written by Miller and Byron Kennedy. The film, starring the then-little-known Mel Gibson, was released internationally in 1980. Its narrative based around the traditional western genre, Mad Max tells a story of breakdown of society, murder and vengeance. It became a top-grossing Australian film and has been credited for further opening up the global market to Australian New Wave films. The movie was also notable for being the first Australian film to be shot with a widescreen anamorphic lens.

It has had a lasting influence on apocalyptic and post-apocalyptic fiction ever since. The film spawned two sequels Mad Max 2 in 1981 and Mad Max Beyond Thunderdome in 1985. A feature film sequel and video game tie-in are currently in pre-production.