Will a 22 rifle kill someone a mile away?

Technically speaking, if one fired a .223 (5.56) it could kill at that range. If you are speaking of a .22LR or .22L, it is almost entirely impossible. The only way that a .22 could kill at that distance, is if you fired it at a very high angle and the bullet somehow landed in the eye socket, or punctured an artery in the arm. Just my $0.02