What happens to neurotransmitters left over in the synapse?

Neurotransmitters left in the synapse after signaling can be removed through several processes. They may be broken down by enzymes, reabsorbed by the presynaptic neuron through a process called reuptake, or diffuse away from the synaptic cleft. This clearing of neurotransmitters is essential for maintaining proper synaptic function and preventing continuous activation of receptors.