Which 2 strata of the epidermis are susceptible to cancer?

The two strata of the epidermis that are most susceptible to cancer are the stratum basale and the stratum spinosum. The stratum basale contains the basal cells responsible for producing new skin cells, and cancers originating from this layer include basal cell carcinoma. The stratum spinosum contains keratinocytes, and cancers arising from this layer can lead to squamous cell carcinoma.