Which classes of hypersensitivity are modulated by B-cells?

B-cells primarily modulate hypersensitivity types I, II, and III. In type I hypersensitivity, B-cells produce IgE antibodies in response to allergens, leading to allergic reactions. In type II, B-cells generate IgG or IgM antibodies that target specific cell surfaces, resulting in cytotoxic effects. Type III hypersensitivity involves the formation of immune complexes by B-cell-produced antibodies, which can deposit in tissues and trigger inflammation.