What is the antidote of pyridostigmine?

The antidote for pyridostigmine, which is a reversible acetylcholinesterase inhibitor, is atropine. Atropine works by blocking the effects of excess acetylcholine at muscarinic receptors, alleviating symptoms of cholinergic toxicity. In severe cases, pralidoxime may also be administered to help restore normal function of acetylcholinesterase if there is significant inhibition.