What are some strategies for utilizing MTG Karn, the Great Creator effectively in a deck?

To effectively utilize MTG Karn, the Great Creator in a deck, consider including artifacts with powerful activated abilities that can be activated from exile. Use Karn's -2 ability to shut down opponent's artifacts and prevent them from activating. Additionally, include cards that can protect Karn from removal spells and ensure he stays on the battlefield to maximize his impact on the game.