What route is best to travel on with large RV from Pismo beach to Las Vegas NV?

The best route for a large RV traveling from Pismo Beach to Las Vegas is to take US-101 South to CA-58 East, then connect to I-15 North toward Las Vegas. This route avoids steep mountain passes and provides ample services along the way. Make sure to stop for fuel and rest breaks in towns like Bakersfield or Barstow, as they offer RV-friendly facilities. Always check for any road restrictions or closures that may affect your journey.