Can you delete a profile on Nintendogs?

To delete your whole game on nintendogs just press and hold the a, b, x, y, l, and r buttons all at the same time while the game is loading prior to the title screen appearing. (Right when it says Nintendo) But beware if you erase all saved data, it and your puppies can never be recovered.

To delete just one dog go to the Dog Hotel and choose donate. Pick the dog you want to get rid of and you'll never see that dog again.