What drugs inhibit the breakdown of bone?

Bisphosphonates are the primary class of drugs that inhibit the breakdown of bone. They work by binding to the bone mineral matrix and preventing osteoclasts from breaking down bone tissue. Other medications, such as denosumab (a monoclonal antibody) and selective estrogen receptor modulators (SERMs) like raloxifene, also have similar effects on bone breakdown. These drugs are commonly used in the treatment of osteoporosis and other bone-related conditions.