Can you take imitrex with Effexor xr?

I wouldn't suggest it. Firstly, imitrex works by blocking the pain receptors in your brain to stop the migraines. It is an abortive medication (stops the migraine from getting worse when you feel it coming on), so if the norco is for the pain of the migraines you may just need to add a preventative medication instead of taking norco. Norco is for moderate to severe pain usually prescribed after surgery, and is very addictive. The preventative medication (a med that keeps the migraines from starting or at least from coming on so frequently) is a better option. If you take the two together you will most likely not be able to function for quite a while, and from what I've read things like vicodin and norco (basically double strength vicodin with less acetaminophen or "tylenol") can cause what's called "rebound headaches" and make your migraines worse or more frequent overall. If the norco is for a different kind of pain, I would suggest taking it at a different time than you take the imitrex so you're not completely out of it. I know when I even take one imitrex, it usually puts me to sleep for approximately 4 hours due to the strength and purpose of the drug. Adding norco would put me out for a long time, most likely all day/night. Just remember norco is a very difficult drug to get off of, highly addictive and habit forming. Be careful with that norco, adding a preventative med would be a much safer and more effective way of managing chronic migraine pain. Hope this helps and that you feel better soon.