Where can estradiol be found and can it be purchased over the counter?

Estradiol is primarily found in the ovaries, adrenal glands, and in smaller amounts in the testes. It can also be produced synthetically for use in hormone replacement therapy and contraceptives. In some countries, certain forms of estradiol, such as topical creams or patches, may be available over the counter, but in many places, it requires a prescription due to its hormonal effects and potential side effects. Always consult a healthcare provider for guidance on obtaining and using estradiol.