Prolonged starvation can lead to severe malnutrition, resulting in the body breaking down fat and muscle for energy, which can cause tissue damage. This state can also lead to complications like infections or sepsis, particularly in cases of weakened immune response. In extreme situations, the lack of nutrients can cause necrosis, or tissue death, which may necessitate amputation of limbs. Additionally, underlying conditions exacerbated by starvation, such as Diabetes, can also contribute to limb loss.
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