How much prazosin can be lethal?

The lethal dose of prazosin, an alpha-1 adrenergic antagonist, can vary widely among individuals due to factors such as age, weight, overall health, and concurrent medications. While there is no established specific lethal dose, doses significantly higher than the therapeutic range (typically up to 20 mg per day) can lead to severe hypotension, cardiovascular collapse, and potentially death. Cases of overdose have been reported with doses ranging from 100 mg to 300 mg, but individual responses can vary. Immediate medical attention is crucial in the event of an overdose.