How are telomeres and telomerase related to aging and cancer?

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2026-05-12 13:30

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Surely you know what DNA is... and a chromosome is a tightly coiled DNA strand in the nucleus of every single cell in your body. A telomere occurs where the DNA is folded over like the twisty wire, the ones everyone uses to tie bread bags. It looks like a cap on the end of the fold. The nucleotide sequence in all animal cells is "TTAGGG" and it repeats over and over again at the end of all chromosomes in your body. To understand how this relates to aging you have to know what the Hayflick Limit is. In a laboratory, human cells have been found to divide only about 50 times before dying. This occurs in your body when more and more cells reach their Hayflick limits and all your systems start to shut down. This is known as aging. The Hayflick Limit, is directly related to telomeres. Everytime a cell in your body divides, it loses a little bit of its telomeres, right up until there is none left, known as Hayflick's Limit. The DNA actually comes apart in the cell and the cell undergoes senescence, or celluar suicide. When too many cells start reaching their Hayflick limits, your old. Now if you get your hands on a steady supply of telomerase, this enzyme will rebuild the telomeres in your body. As long as you have a continuous supply, you will live a lot longer. No one has really seen this, but human cells in a laboratory will divide well past their Hayflick Limit's. Giant Sea turtles naturally express telomerase, and no one has ever recorded one's whole life span. This is because none of the ones born in captivity have ever died of natural causes. It is theorized they live around 1000 years, however more telomerase would likely extend their lifespans.

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