When do missense mutations cause large deletions?

Missense mutations typically do not directly cause large deletions; they change a single amino acid in a protein sequence. However, they can indirectly lead to large deletions if they disrupt the stability of the protein or alter its function, potentially resulting in genomic instability during replication or repair processes. Additionally, missense mutations in genes involved in DNA repair mechanisms could increase the likelihood of large deletions occurring in the genome.